With the campaigning over it is time for voters to have their say on the UK's future membership of the 28-nation bloc.
Voters go to the polls later in a historic referendum to decide whether Britain should remain in or leave the European Union.
The first people able to cast their ballot are in Gibraltar where polling stations opened at 6am UK time and will close at 9pm.
Across the UK, polls open at 7am and close at 10pm.
On the ballot paper, voters will be asked: "Should the United Kingdom remain a member of the European Union or leave the European Union?".
They will then choose whether they want to "Remain a member of the European Union" or "Leave the European Union" by placing a cross in the appropriate box.
A record number of voters - some 46.5 million - are eligible to take part in the referendum, according to figures from the Electoral Commission.
Counting will begin as soon as polls close.
The country has been divided into 382 voting areas, each of which will declare its own result.
This is made of 380 local authorities across England, Wales and Scotland. Northern Ireland counts as one area, as does Gibraltar.
The overall result for the whole of the UK will be announced in Manchester, but only when all 382 areas have declared.
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